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Ozempic and Mounjaro are approved for type 2 diabetes

GLP-1 receptor agonists stimulate insulin secretion, suppress glucagon release, and slow gastric emptying to control blood glucose and support weight management

These simulations indicate that the ECD in the apo-state GLP-1R is quite dynamic and that the TMD-interacting closed conformations are energetically favorable in the absence of the peptide agonist
GLP-1 was identified in the early 1980s, and its insulinotropic and anorectic properties were rapidly established