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This was emphasised in the CANTOS trial, in which a monoclonal antibody targeting IL-1 in individuals with established atherosclerotic CVD and evidence of systemic inflammation reduced the risk of major adverse cardiovascular events (MACE) by 1517%, an effect that was likely to be mediated by reductions in serum CRP concentrations [80, 81]

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doi: 10.1007/s00125-017-4354-8 6 UngerRHOhnedaAValverdeIEisentrautAMExtonJ

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