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Mechanistic and Molecular Pathway Studies Several biological pathways have been proposed to explain a potential association between GLP-1 receptor agonists and cancer risk reduction, including improved insulin sensitivity, attenuation of systemic inflammation, modulation of gut microbiota composition, and downstream effects on proliferative signaling pathways such as the mammalian target of rapamycin (mTOR)

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c , NCI-H716 cells were treated with calcium inhibitors (10 M) 15 min before the P9 treatment (100 g ml 1 ) for 2 h, then GLP-1 secretion was quantified (n = 6 per group)

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Literature Search The literature review involved a comprehensive search of reputable medical databases