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When combined with GLP-1 action, GIP helps reduce overall calorie intake while improving metabolic flexibility

Weight regain after stopping semaglutide affects most patients, with studies showing average weight recovery of 50-70% within one year of discontinuation

We know GLP-1 medications reliably produce weight loss through a combination of appetite suppression, reduced gastric emptying, and decreased overall intake (Read my full GLP1 deep dive here)

GLP-1 medications slow gastric emptying, which is one of the ways they increase satiety and moderate post-meal blood sugar rises

The slowing of gastric emptying and alterations in nutrient absorption are likely contributors

Some patients experience mild nausea or stomach upset as their body adjusts