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The FDA stated the semaglutide injection product shortage was resolved on February 21, 2025, according to the FDA drug shortage database

A few rely mostly on anecdotal reports

FDA does not review compounded medications for safety or efficacy

What changed: after the FDA declared the semaglutide shortage resolved, the broad, shortage-era compounding largely ended, with enforcement timelines through 2025

This leads to decreased caloric intake, which is the primary driver of weight loss

35 A relatively small open-label study on eight patients with diabetes mellitus and biopsy-proven NASH found that 28 weeks of exenatide treatment made no significant difference in liver histology, and only three of the eight subjects did meet the primary end point of improved histopathology, with 1 to 2 point fibrosis improvement seen in four subjects and fibrosis worsening by 1 point in one subject and staying the same in three subjects