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Glucagon-like Peptide-1 receptor agonists (GLP-1 RA) and metabolic and bariatric surgery (MBS) both improve cardiovascular outcomes in patients with severe obesity and type-2 diabetes (T2D)

Semaglutide remains active in the body for approximately 7 days with a half-life of 15-19 hours, but individual clearance rates vary significantly based on metabolic biomarkers and genetic predispositions

Clinical evidence shows GLP-1 medications can be effective at lower body weight goals when combined with personalized dosing and lifestyle support

In the process, this review will also provide a physiological overview of the incretin system and how key components function in T2DM.

Metabolic testing, GLP-1 medications, lifestyle modification through direct primary care.

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