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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Jeppesen PBJCOiE, Diabetes, Obesity Gut hormones in the treatment of short-bowel syndrome and intestinal failure

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Overexpression of Cxcl2 causes increased inflammation in WAT and to the cardiovascular system [106,108]

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Inside visceral fat, an enzyme called 11-beta-HSD1 converts inactive cortisone into active cortisol locally, creating a pool of fat-derived cortisol on top of whatever the adrenals produce (PMC7827500, Fella Health)

Given their small populations, regional pooled procurement could turn that threat into transformational opportunity
