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Regarding the ranking of the most superior treatment, SGLT-2 inhibitor showed the leading effect (SUCRA 76.4%), followed by GLP-1 agonist (SUCRA 71.7%)

Reduced carbohydrate availability constrains glycolytic flux and increases dependence on lipid-derived substrates

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Dupre J, Ross SA, Watson D, Brown JC

According to the Indiana University School of Medicine, prior research suggests that, in the United States alone, the use of GLP-1s have increased by fortyfold between 2017 and 2021