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Both compounds reduce fat mass, but tirzepatides GIP receptor engagement may contribute to preferential adipose tissue reduction, including visceral fat, through mechanisms that are still being characterised in preclinical and clinical models [5]
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Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]
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