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The SURMOUNT-1 trial showed tirzepatide 15 mg produced 20.9% mean weight loss vs 14.9% for semaglutide 2.4 mg in head-to-head comparison (Jastreboff et al., NEJM 2022)

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Updated evidence on cardiovascular and renal effects of GLP-1 receptor agonists and combination therapy with SGLT2 inhibitors and finerenone: a narrative review and perspectives

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