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Specifically, neuropeptide Y/agouti-related protein (NPY/AgRP) neurons control appetite by the orexigenic effect47), and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons are sensitive to peripheral hormones such as insulin and leptin by anorexigenic effects48)

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Author Contributions Conceptualization, F.B

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Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) (Grant Number: 454472/2014-5)

In-use pens may be stored at room temperature up to 30C for a maximum of 6 weeks, after which they must be discarded regardless of remaining doses