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The key risks include gastrointestinal bleeding, sexual dysfunction, hyponatremia, serotonin syndrome, discontinuation syndromes, and cardiovascular complications

However, this early loss includes both water weight and actual fat reduction, so the rate may slow slightly after week four

After 68 weeks on semaglutide, patients had lost an average of over 15% of their body weight

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Head-to-Head Trial Results One study found that patients lost an average of 22.9% of their body weight after 3.5 years on Mounjaro