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Exposure to sugars induces rapid GLP-1 secretion from T1R3-sensitive cells, following a dose-dependent pattern where higher stimulus concentrations lead to greater secretionan effect blocked by GLP-1 receptor antagonists (61, 67)

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Triple Receptor Binding Profile Glucose-Dependent Insulinotropic Polypeptide Agonism : The structural core of the molecule heavily favors GIP receptor affinity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Speakman J.R., de Jong J.M.A., Sinha S., Westerterp K.R., Yamada Y., Sagayama H., Ainslie P.N., Anderson L.J., Arab L., Bedu-Addo K., et al