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While semaglutide activates only the GLP-1 receptor, tirzepatide is a dual agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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consumers (Amin et al., 2023)

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The manufacturer, Eli Lilly Co., has submitted orforglipron to the FDA for approval for use in weight management, with a decision expected in the second quarter of 2026

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Innovation potential expands to novel conveyance frameworks, combination treatments, and personalized medication approaches

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In discordance with the previous study, it was reported that exenatide injected systemically or centrally into the NAc shell region decreased oxycodone selfadministration, as well as responding in a reinstatement paradigm (Zhang et al., 2020)

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We recommended counseling and that all female patients use contraception to prevent unintended pregnancy while on GLP1-RAs [177]

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