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If DAO activity is lowor if histamine levels become excessivesymptoms can spiral

Patients with a history of pancreatitis, gallbladder disease, or severe gastroparesis may require careful consideration of risks versus benefits

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Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin

They slow down gastric emptying (so food stays in the stomach a bit longer) which helps moderate how fast sugar hits the bloodstream

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