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Reviews in Endocrine & Metabolic Disorders, 23 (5), 979994

Whether these actions are conserved in humans, and depend on direct or indirect actions of GIP on the cardiovascular system, is currently unknown

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As such, we did not consider open-label status as a source of bias, given that measurement of HbA 1c is an objective outcome and thus is not affected by blinding status [15]

It ebbed and reappeared again around week four, which makes sense from what we know of tirzepatides half-life (of approximately five days), as it takes roughly four to five weeks of regular dosing to reach a steady state in the body where drug levels stabilise at a consistently higher baseline than in the early weeks