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Eli Lillys retatrutide has demonstrated an average weight loss of 28.3% over 80 weeks on the highest dose.

Five things you should know about using GLP-1 drugs for weight loss

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These headwinds have led to a sharp decline in its stock price, raising questions about the long-term impact of its gamble.

Understanding their distinct mechanisms, clinical evidence bases, and how genetic and biomarker data inform personalized treatment selection helps patients and providers make evidence-based decisions