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This review explores the complex interplay between hyperkalemia and the use of guideline-directed medical therapies (GDMT), such as reninangiotensinaldosterone system inhibitors (RAASi) and steroidal mineralocorticoid receptor antagonists (sMRAs), including spironolactone and eplerenone, which are currently recommended in guidelines for improving outcomes in heart failure with reduced ejection fraction (HFrEF)

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Once inside, they: Reduce neuroinflammation (inhibit NFB, microglial activation) Boost synaptic plasticity (enhance neuron connectivity) Improve glucose uptake (support brain energy metabolism) Local GLP-1 from neurons likely doesnt drive these effectspharmacological action dominates. | 10 comments on LinkedIn

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