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GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures

(2023) Glucagon-Like Peptide-1 Analogue in the Management of Rebound Intracranial Hypertension: A Case Report

These findings highlighted retatrutides potential as a potent therapeutic agent for obesity and metabolic disorders

[18] Semaglutide (Wegovy) is now available through NHS specialist weight management services for adults with at least one weight-related comorbidity and a BMI of 35 kg/m or above (or 32.5 kg/m for certain ethnic groups), as recommended in NICE TA875

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GLP-1 RAs should be considered as an add-on to SGLT2i therapy for those with cardiometabolic complications with elevated HbA1c, BMI 35 kg/m 2 , and comorbidities