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In real-world practice, especially in the resource-limited settings, these findings may help support more nuanced, individualized decisions

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Finally, patients should inform their provider if they are considering magnesium supplementation exceeding 350 mg daily (the Tolerable Upper Intake Level for supplemental magnesium), as excessive intake can cause diarrhea and other adverse effects

We estimate that the cost of GLP-1 drugs for obesity is currently about 10% of total pharmacy spending

Typical dosing is 500-1000 mg twice daily with meals

Wegovy is still a strong, evidence-based option, and sometimes insurance coverage, medication access, or tolerability makes it the smarter starting point