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The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the already wildly popular drugs use beyond diabetes and weight loss and offering a new treatment option where few are available

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Tirzepatide, a dual agonist with even stronger body weight reduction effects than semaglutide [66] reduces energy intake of approx

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Most recently, third-generation multi-agonists (tirzepatide, retatrutide, and survodutide) targeting complementary incretin receptors have demonstrated unprecedented metabolic efficacy, representing a paradigm shift in both diabetes and obesity management [11,12]

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