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Over time, the GLP-1 population has evolved to include an increasing prevalence of patients with no prior antidiabetic prescriptions and with fewer diabetes diagnoses

Short-acting agents undergo renal clearance, so they require once-daily (lixisenatide) or twice-daily (exenatide BD) dosing

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in Spain, its current prevalence ranges between 2833%11,12 and it is a recognized as a cardiovascular risk factor and increases the mortality in this population.1315 Furthermore, in patients with DM2 and advanced CKD there are limitations in the prescription of certain antihyperglycemic drugs (e.g., metformin or sulfonylureas) and there is an increased risk of hypoglycemia with antihyperglycemic treatment,16 a complication that is associated with increased cardiovascular risk17 and hinders the achievement of glycemic control targets

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