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Liraglutide and polycystic ovary syndrome: is it only a matter of body weight

The two pathways converge on the same outcome, reduced food intake, but they get there through different neurological routes

Genome-wide association analyses have detected critical polymorphisms in genes regulating hepatic lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), which promote intrahepatic triglyceride accumulation by impairing lipid remodeling or very-low-density lipoprotein (VLDL) secretion [16,17]

Among GLP-1RA users, 26.36% discontinued treatment during follow-up, while 22.68% experienced interruptions

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