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Tirzepatide works by: Slowing gastric emptying , which prolongs the feeling of fullness after meals Reducing appetite through effects on brain centres that regulate hunger Improving insulin secretion in response to elevated blood glucose Decreasing glucagon secretion , which helps lower blood sugar levels Clinical trials have demonstrated that tirzepatide can lead to substantial weight losswith dose-dependent reductions of approximately 1520% of body weight over 72 weekswhen combined with lifestyle modifications

These include pancreatitis, gallbladder issues, and potential thyroid concerns (semaglutide carries a boxed warning about medullary thyroid carcinoma in animal studies)

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This is a broad-scope review that brings together everything we know about assessing -cell function in type 2 diabetesspanning from bench to bedside

Cardiovascular markers Both compounds showed improvements in cardiovascular risk markers in their respective trials