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It is important to note that GLP-1 receptor agonists should be used with caution in patients with a history of pancreatitis, and treatment should be discontinued if pancreatitis is suspected, as stated in the MHRA SmPC for Ozempic
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It supports significant weight loss in individuals with obesity or related health conditions like type 2 diabetes and hypertension

A Phase 2 clinical trial published in the New England Journal of Medicine (2023) demonstrated participants receiving retatrutide achieved up to 24.2% mean weight reduction over 48 weeks the highest reduction reported for any investigational compound in its class at that time
