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Meanwhile, both the insulin-like growth factor-1 (IGF-1) released during bone resorption and TGF- are key signals for MSC recruitment to the site of bone resorption, and their expression promotes the return of MSCs or early osteoblast precursor cells to the resorption traps, ultimately allowing them to differentiate and secrete the molecules that form the replacement bone (Tang et al., 2009)

More patients discontinued semaglutide than placebo (16.6% vs