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While short- and medium-term impacts have been looked at, studies to determine whether there are long-term side effects will be necessary, according to Manning

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Although the majority of first-time prescriptions occurred in the 45-64 age group, a higher proportion of patients with off-label prescriptions were female (off-label: 69%, on-label: 61%) and between 18-25 (off-label: 30%, on-label: 22%)

semaglutide in nine SUSTAIN phase 3a clinical trials (SUSTAIN 16, two Japanese trials and the China Multi-Regional Clinical Trial) [8,9,10,11,12,13,14,15,16] and four phase 3b clinical trials (SUSTAIN 710) [17,18,19,20] and oral semaglutide in the 10 PIONEER phase 3a clinical trials (PIONEER 110