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Osteoarthritis (e.g., STEP 9)
Inhibition of dipeptidyl peptidase-4 impairs ventricular function and promotes cardiac fibrosis in high fat-fed diabetic mice
In this study we investigated the effect of GLP-1R agonist liraglutide on blood pressure, hydration status, natriuresis and the activity of the reninangiotensinaldosterone axis in patients with diabetic kidney disease after a dose of liraglutide compared to placebo
2.2 Rat studies Studies with laboratory rats were conducted in accordance with the standards of the Federal Republic of Germany (similar to AAALAC equivalents) under license numbers SYN01/16, SYN07/20, and SYN01/22, provided by the Regierungsprsidium Tbingen ethics committee
doi: 10.1056/NEJMoa2107519
Clinical Trials
