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However, contact your provider if constipation persists beyond four weeks despite hydration and dietary changes, if you experience severe abdominal pain or bloating, or if you cannot have a bowel movement for more than three days

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Jensterle M., Rizzo M., Haluzk M., Jane A

The key is understanding these indirect pathways

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When you activate both receptors together, the effects on appetite, glucose regulation, and fat metabolism exceed what either achieves alone