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Some clinicians recommend extending dose escalation intervals specifically for patients prone to GI side effects

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Elevated intracellular cGMP levels activate protein kinase G type 1 (PKG-1), which lowers cytosolic calcium concentrations and activates calcium-dependent potassium (KCa) channels, favoring VSMC hyperpolarization and smooth muscle relaxation [22,23]

These medications can be highly effective for managing blood sugar and weight, but they may also have implications for eye health, especially for people with diabetes or existing eye conditions

Although case reports have described levothyroxine over-replacement and subsequent AF/Aflutter following GLP-1RA initiation [37], no largescale study has evaluated the real-world effect of GLP-1RA initiation on cardiovascular outcomes

One Mayo Clinic forum discussion acknowledged that an alternating 6-month approach is "creative" and might allow you to get benefits from both while minimizing cumulative side effects