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Additionally, a large meta-analysis of 94,885 patients with Medicare demonstrated a 37% reduction in mortality 4 years after bariatric surgery with benefits evident in males and females as well as individuals with and without a pre-surgical diagnosis of diabetes [22]

For example, the small-molecule GLP-1 receptor agonist lotiglipron was terminated by Pfizer due to unfavorable hepatic safety signals such as elevated transaminase levels

( 10.1038/nm.3128) [DOI] [PubMed] [Google Scholar] Knop FK Urva S Rettiganti M Benson CT Roell WC Mather KJ Haupt A & Pratt E

K., Kochanek, S

Multiple randomized controlled trials and meta-analyses have examined hepatic endpoints in patients with type 2 diabetes and NAFLD

Recent studies suggest that glucagon receptor signaling is disrupted in NAFLD, indicating that supra-physiological glucagon receptor agonism might represent a new NAFLD treatment target