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Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GLP-1 - Glucagon-like peptide-1 OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Mounjaro) - marketed for diabetes Tirzepatide (Zepbound) - marketed for weight loss MECHANISM OF ACTION GLP-1 and GIP GLP-1 stands for "glucagon-like peptide-1," and GIP stands for "glucose-dependent insulinotropic polypeptide." GIP is also sometimes referred to as "gastric inhibitory polypeptide." GLP-1 and GIP are hormones secreted by specialized cells in the small intestine in response to food consumption

This inconsistency sometimes leads people to think the medication has stopped working when the issue is actually variable absorption from inconsistent technique

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications

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If possible, work with your provider to taper your dose gradually rather than stopping cold

A study conducted on 76 patients with advanced CKD (stage 4 or higher) who began semaglutide treatment between January 2018 and January 2023 revealed that many safely reached therapeutic doses