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In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than those recommended for skeletal muscle spasm, some of the more serious central nervous system reactions noted with the tricyclic antidepressants have occurred (see WARNINGS, below, and ADVERSE REACTIONS)

DOI: 10.1016/j.freeradbiomed.2013.11.029 Moratilla-Rivera, I., Perez-Jimenez, J., Ramos, S., et al

1 GLP-1 also delays gastric emptying and, probably mainly through central nervous system effects, promotes satiety

weight loss decreases overall fat deposition

Digestive issues Difficulty in moving to maintenance or transitioning off the medications Not knowing what to eat to maximize the benefits of the medications Other challenges include slower metabolism, difficulty keeping weight off, and side effects that might make sticking with the medication harder

, Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
