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When adding a GLP-1 to an existing Tresiba regimen, most guidelines recommend reducing the Tresiba dose by approximately 20% to avoid hypoglycemia as the GLP-1 begins its own glucose-lowering effects

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Consistent with this, i.c.v

We found that the maternal blood GLP-1 concentration decreased progressively during pregnancy, contrary to the increase in pancreatic islet GLP-1 content (15, 19)

Patients often report increased energy levels, better mood, and a general sense of well-being

Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial