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For molecular biologists, this represents more than a new class of medicineits a rewriting of biology itself, where the transcript becomes the treatment and the code becomes the cure

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GHSR is a member of the seven transmembrane G protein-coupled receptor family, and is expressed in multiple brain regions, including the hypothalamus and pituitary [3], as well as in several pancreatic cell types (, , and acinar cells) [4, 5], throughout the gastrointestinal tract (stomach, intestine and vagal afferent neurons) [6], and in the adipose tissue [7]

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Two classes of newer anti-hyperglycemic agents can reduce CV risk and events in patients with T2D, namely glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors

17, 2024) (Canada)