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Are there any long-term safety concerns with tirzepatide

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GLP-1 agonists, though effective, can cause nausea, diarrhea, and (in rare cases) more serious issues like pancreatitis

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Diabetic gastroparesis Gastroparesis is common in people with diabetes and roughly up to a third or slightly more of people with type 1 or type 2 diabetes may develop gastroparesis

Other GLP-1 medications like Mounjaro and Zepbound (tirzepatide) have been proven in head-to-head trials to promote significantly more weight loss and will have a slightly different timeline