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This might be attributed to the attention the study paid to providing adequate diet and exercise advice to the participants

The European Medicines Agency (EMA) and Heads of Medicines Agencies (HMA) have published recommendations in tackling the shortages, warning patients that the medications should only be obtained with a prescription and through a pharmacist, cautioning against online purchases except from trusted sources, where there is proper medical supervision (EMA 2024

These advances have expanded the role of GLP-1RAs from short-acting injectables to multifunctional oral formulations, creating new opportunities for targeted nanoplatforms in both metabolic and non-metabolic diseases [100, 101]

The use of conjugates such as GLP-1/T 3 could serve as a Trojan horse delivery system where internalisation through a functional GLP-1 receptor might deliver T 3 to the brain, ameliorating the disease (and potentially other similar human genetic deficiencies)