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Most people notice reduced appetite within 1-2 weeks of starting GLP-1 medications

79 WangY.SunL.HeG.GangX.ZhaoX.WangG.et al (2021)

These medications appear to have benefits beyond weight loss

Gastroparesis warning signs include nausea and vomiting that persists beyond the initial adjustment period, severe bloating that does not improve with dietary changes, inability to eat normal portions even weeks after dose stabilization, and unexplained weight loss that goes beyond your target
and Trujillo J

Current evidence does not establish a causal relationship between GLP-1-based weight loss injections and most cancers in humans
