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10.1056/NEJMoa1612917 [DOI] [PMC free article] [PubMed] [Google Scholar] 221.Hernandez AF, Green JB, Janmohamed S, D'Agostino RB, Granger CB, Jones NP, et al

Psychiatry 26, 43944408

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Retatrutide has developed one of the most rapidly growing pre-clinical research profiles of any metabolic peptide currently in active study: Pre-clinical metabolic research in obese animal models has reported body weight and fat mass reductions with Retatrutide that exceed those observed with dual-receptor compounds including Tirzepatide at comparable doses and suggesting that the addition of glucagon receptor engagement to combined GLP-1/GIP agonism produces meaningfully greater metabolic effects in experimental settings