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In addition to glycemic improvements, retatrutide showed remarkable effects on body weight

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Hepatic and renal functions were assessed by measuring changes in the plasma concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT) (hepatic function) and creatinine (renal function) respectively

La sealizacin intracelular incluye, adicionalmente, diversas vas, como el reclutamiento de beta arrestina-1, que modula la internalizacin del receptor y su desensibilizacin, as como los efectos de algunos agonistas del GLP-1R3,4