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The complaint alleges that, in reality, defendants understated the ongoing impact of the personalization exception to the compounded GLP-1 exclusion, overstated the likelihood that patients would switch to Novo's branded alternatives, and overstated the GLP-1 market's expansion or Novo's ability to penetrate it to achieve continued growth

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However, a preclinical study conducted in high-fat-diet-fed obese IR mice documented that tirzepatide enhances insulin action to a greater extent than semaglutide, since it exerts both weight-dependent and weight-independent (through GIP receptor agonism) insulin-sensitizing actions [196]