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The clinical relevance of these findings is underscored by the safety profile of GLP-1 agonists in long-term use and their established efficacy in reducing cardiovascular events

K., & Bain, S

JAMA (2019) 321(15):14578

Whilst exenatide was initially developed based on the exendin-4 peptide found in Gila monster venom, even this first-generation medication is produced synthetically through biotechnology rather than extracted from lizards

17 Myth : People dont have to exercise or eat healthfully when taking GLP-1 drugs

Also, GLP-1 RA seems to regulate glucose homeostasis by exhibiting glucagonostatic effects meaning suppression of glucagon by acting on pancreatic cells, which in turn reduce hepatic production of glucose (52)