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SELECT Trial Cardiovascular Disease 20% reduction in the risk of cardiovascular events 37% risk reduction in a broader set of secondary outcomes (including cardiovascular death and stroke) FLOW Trial Chronic Kidney Disease: Novo Nordisks clinical trial , which enrolled 3,533 people with type 2 diabetes and CKD, was ended early as a result of clear efficacy

See JAMA Network Open study

But the signals are everywhere

About 30% of patients experience abdominal issues such as nausea, diarrhea, or constipation

Increased risk of aspiration pneumonia associated with endoscopic procedures among patients with glucagon-like peptide 1 receptor agonist use

In addition to differences in patient genetics and pathophysiology, drug-drug interactions could contribute to the heterogenous response to GLP-1 M