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If you run 175 statistical tests, on average 5% (or about 8 or 9) of these will show up as significant associations just by random chance

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Compared to GLP-1 RAs, no significant difference was observed with SGLT2is (WMD: 160

Additionally, tirzepatide demonstrates bias at the GLP1R, favoring the synthesis of cAMP over the recruitment of -arrestin [1]

Therapeutic Advances in Endocrinology and Metabolism 122042018821997320