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They excluded those with major depressive disorder within the previous two years, as well as those reporting certain other severe or recent mental health conditions, according to the article published in JAMA Internal Medicine

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This review seeks to provide further clinical context both to assist in the creation of future high-quality evidence and guidelines as well as to assist providers in making informed, evidence-driven decision to enhance outcomes and minimize risks in the perioperative period for this patient population

Soluble fiber can help manage the occasional diarrhea some patients experience, while insoluble fiber is particularly helpful for the more common constipation issues
As of June 2026, there is no FDA-approved oral tirzepatide

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