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No evidence of cardiac, hepatic, or renal toxicity, changes in serum lipids, or clinically relevant changes in laboratory parameters, vital signs, electrocardiograms, or abnormal findings upon physical examinations have been observed

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Long-Term Risks of Repeated Overdosing Intentionally or accidentally taking higher-than-prescribed doses repeatedly can cause lasting damage to your gastrointestinal system

Bridges HR, Jones AJ, Pollak MN, Hirst J (2014) Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

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Emerging literature suggests that like their ability to reduce desire for food, GLP-1 agonists can also reduce desire for other hedonistic pleasures such as cannabis [13,14], cigarettes [13], alcohol [13], opiates [15,16], and sexual desire [17] in patients with obesity or diabetes