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Discontinuation rates due to gastrointestinal adverse effects ranged from 47% across clinical trials, as reported in the FDA prescribing information, indicating that while nausea and vomiting are common, they are tolerable for most patients

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Could this be the beginning of phenotype-guided OSA therapy

Focus on balanced nutrition with adequate protein, as reduced appetite during treatment may sometimes lead to insufficient protein intake

Another important detail is that the GIP component may help improve tolerability for some patients compared to older GLP-1 medications alone

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