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Depending on the medication and individual response, patients typically lose between 10-20% of their body weight

A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

Our findings show that in the future, GLP-1 targeting medications could provide a much-needed treatment option for patients with heart failure. Authorship: In addition to Krger, Mass General Brigham authors include Sebastian Schneeweiss, Kenshiro Fuse, Sushama Kattinakere Sreedhara, Georg Hahn, and Shirley V

[DOI] [PubMed] [Google Scholar] 44.Ebong IA, Goff DC Jr, Rodriguez CJ, et al

10.1210/en.2018-00004 177

Current studies examine whether these peptides can protect against cardiovascular and neurodegenerative conditions, hinting at a broader scope for laboratory research