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Focusing on the cardiovascular system, the endocrine and paracrine effects of adipose tissue play a core role in its physiological and pathological functions, underlying the importance of exploring the crosstalk between them [53, 54]

The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]

There is also a practical distinction between degradation that happens gradually at moderate temperatures and degradation that happens rapidly at extreme temperatures

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