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GLP-1 receptor agonists directly activate GLP-1 receptors and are FDA-approved for both glycemic control and weight management at specific doses, while DPP-4 inhibitors prevent breakdown of endogenous GLP-1, are used only for glycemic control, and are weight-neutral

The main target of current PD treatment is the restoration of dopamine levels, as the deficiency of this neurotransmitter is the main cause of PD

Demand increased sharply as semaglutide and tirzepatide medications became associated with substantial weight loss, leading more patients without diabetes to use GLP-1 drugs

doi: 10.1007/s00125-016-3874-y, 37 FeinglosM

Ellingsgaard, H

Acute Inflamm Metabolism Inflamm